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Digestive Enzymes and Probiotics


Our Digestive Enzymes and Probiotics is a high-potency formula created specifically for dogs and cats. Formulated with higher amounts of plant enzymes and probiotics needed to help your animals properly digest raw food, kibble, canned and home-prepared diets. Most other enzyme and probiotic formulations on the market do not have adequate amounts of the important enzymes that help your animal quickly and efficiently digest their meals.

This is a superior enzyme formula with 13 specialized enzyme strains and the addition of 5 billion CFU per gram of 13 species of beneficial bacteria and will help in situations where there are nutritional deficiencies, food allergies, inflammatory bowel issues, autoimmune issues and arthritis - all of which can result from the poor digestion of the food your dog or cat is eating.



What to Look for in a Superior Digestive Enzymes and Probiotics Supplement...

High Amount of Proteases for Proper Protein Digestion

Our enzyme supplement has the highest amount of proteases compared with other formulas for pets found on the market. Proteins, including glutens which are a type of protein, are the particles largely responsible for inflammatory conditions in the body and food allergies when not fully digested.

Plant Sourced Enzymes

Our enzyme formula uses a variety of plant-based enzymes that will work the most efficiently with your dog or cat's physiology. Enzymes from plant sources, many of which are grown in specialized laboratory settings, remain active in environments ranging from the upper stomach to the small intestine where the majority of your dog and cat's digestion occurs. Pancreatin and other animal based enzymes are secreted by the pancreas in the upper part of the small intestine. The pH in this area is generally around 7.0-9.0 and is the only environment in which these enzymes will be active. However, the acidity found in your dog or cat's stomach varies between a pH of 4-5 (in the upper stomach) down to 1-2 (in the lower stomach). The result is that the majority of animal based enzymes, like pancreatin, trypsin and chymotrypsin, will not survive the acidity of the stomach to aid your pet's digestion.

An Enzyme Called Peptidase

Our enzyme formula contains Peptidase. This is a specialized protease enzyme that helps to quickly hydrolize proteins from gluten in the stomach. This is preferred because if these proteins are not broken down enough in the stomach, exorphin peptides can be created in the small intestine. Studies show these peptides can be responsible for many of the digestive sensitivities animals and people experience and even behavioral problems in children (maybe some pets also?). This enzyme is especially important for pet foods and treats containing sources of gluten, but helps to digest other proteins as well by further breaking down protein peptides into amino acids - a step not provided by other pet digestive enzyme supplements.

No Unhealthy Additives

Our formula is made with all-natural, whole food ingredients. Absent are the fillers that increase packaging bulk and "flow agents" that make manufacturing faster and easier. Ingredients we avoid, but many of our competitors do not, include lactose, magnesium stearate, maltodextrin, stearic acid, calcium stearate, scorbyl palmitate, silicon dioxide, and microcrystalline cellulose among others.

Manufactured in a USA GMP Certified Facility

Our Digestive Enzymes and Probiotics formula is manufactured right here in the USA in a GMP (Good Manufacturing Practice) standards certified facility. Not all of our competitors products can state that especially those manufactured in China where these standards are not followed.

Use only Human Grade Ingredients

Our products are manufactured using human grade ingredients. In the pet industry this is far from the rule as many companies use pet quality ingredients, those considered "not fit for human consumption".

Compare Our Formula

Desirable attributes are highlighted in GREEN

(Amounts adjusted for one gram per serving and uniform measurements)

Scroll to right to view entire table.

  Our Formula Dr. Mercola Animal Essentials Only Natural Pet Prozyme Nature Vet Flying Basset Wholistic Pet Herbsmith
350,000 FCC 50 mg (not listed in industry standards) 20,000 135,000 120,000 22,100 11,000 Not listed in industry standards 393,000
Protease 6.0 2,000 HUT None None None None None None None None
Protease 4.5 21,000 HUT 2,500 20,500 HUT None None None 12,500 Not listed in industry standards 5,625
Protease 3.0 50 SAPU None None None None None 100 None None
Peptidase 500 HUT None None None None None None None None
Amylase 5,000 DU 2,500 3,150 2,025 2,000 2,320 2,500 Not listed in industry standards 3,750
Lipase 750 FIP 500 662 562 500 525 500 Not listed in industry standards 750
Glucoamylase 6 AGU None None None None None None None None
Cellulase 350 CU None 110 CU 55 50 75 500 Not listed in industry standards 600
Hemicellulase 250 HCU None 100 HCU None None None None Not listed in industry standards None
Maltase 50 DP None None None None None None None None
Alpha-Galactosidase 50GaIU None None None None None None None None
Beta-Glucanase 2,000 HUT None None None None None None None None
Probiotics 5 Billion None 100 Million None None 100 Million None 10 Billion* 5 Billion (adjusted for equal serving)
# of Probiotic Species 13 0 1 None None 1 None 2 3
FOS FOS Free! No No No No Yes No Yes Yes
Whole Food Prebiotics YES! No No No No No No No No
Undesirable Additives None Yes - Animal derived enzymes, cellulose Yes - Calcium Sulfate Yes - Lactose Yes - Lactose Yes - Maltodextrin Not Listed Not Listed Yes - Maltodextrin, sodium silico aluminate (dessicant), stearic acid

*Excessive amounts of probiotics as seen in certain formulas, especially with a limited number of species, can cause digestive tract imbalances and GI disturbances.

Why we are Proud to be FOS Free:

Fructooligosaccharides, more commonly known as FOS, is a class of simple carbohydrates found naturally in certain plants, such as Jerusalem artichokes, onions, and bananas. Virtually, all of the FOS added to probiotic products in the United States is chemically manufactured. A Japanese process is utilized in turning white, bleached cane sugar, by the action of a fungal enzyme, into FOS - a sugar polymer that our bodies cannot digest.

In 1990, Coors Biotech, in an effort to introduce FOS into the food chain of the United States, prepared a GRAS (generally recognized as safe) petition to include FOS as a human food ingredient. As several years of FOS-safe food sales are needed before this approval, the probiotic market was chosen as an easy, nonthreatening way to get the product 'out there.' The health food industry became an ideal test market.

The addition of FOS in probiotic products is becoming a common practice. Many probiotic manufacturers claim FOS is beneficial in that it feeds friendly bacteria. Those who manufacture high-quality probiotics, however, do not believe in using FOS. Instead, their products require one important component - the valuable supernatant, which naturally and specifically provides food for the bacteria.

Prudent probiotic manufacturers are concerned with the safety issue of FOS. According to a study conducted by the Joint Expert Committee on Food Additives (JECFA) of the Food and Agricultural Organization and World Health Organization (FAO/WHO), the consumption of FOS may cause intestinal problems, such as bloating, abdominal pain, and copious amounts of gas.

There are a number of additional reasons why some manufacturers of high-quality probiotics do not add FOS to their products. They are:

  • FOS is manufactured by chemical synthesis. The ingredient is, therefore, not natural, but a chemical additive and may pose toxicological dangers.
  • FOS is a sugar derivative, therefore, those with a yeast infection should avoid it.
  • The stability of FOS is poor. The industrial production of purified FOS is a problem and still in the developmental stage.
  • FOS is inert in the mouth and small intestine because it is not digestible (similar to olestra). It is digested in the colon by the bacteria and may, therefore, change the metabolic activity of the colon, resulting in abnormal functions.
  • FOS stimulates the growth of Klebsiella and possibly other pathogenic organisms. In one study, Klebsiella has been associated with the autoimmune disease ankylosing spondylitis.
  • FOS is known to be species as well as strain specific. In other words, not all beneficial bacteria like the FOS diet.

As always we try to stay informed and do better than our competitors. Not just to say we do but for the health of our pets and yours. That is why we use a whole food blend of prebiotics in our Digestive Enzyme and Probioitc formula and not FOS.


Deanna posted the following excerpt from Probiotics: Nature's Internal Healers by Natasha Trenev: FOS -Fructooligosaccharides. Retrieved from

Ingredients per 1,000 mg (one gram)

Digestive Enzymes

Bromelain - 350,000 FCCPU
Protease 4.5 - 21,000 HUT
Protease 3.0 - 50 SAPU
Protease 6.0 - 2,000 HUT
Peptidase - 500 HUT
Amylase - 5,000 DU
Lipase - 750 FIP
Glucoamylase - 6 AGU
Cellulase - 350 CU
Hemicellulase - 250 HCU
Diastase - 50 DP
Alpha-Galactosidase - 50 GaIU
Beta-Glucanase - 10 BGU

Probiotic Blend 5 Billion CFU

Equal Proportions of the following species of beneficial bacteria:

Bacillus subtilis DE111®
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus reuteri
Lactobacillus bulgaricus
Lactobacillus plantarum
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactobacillus casei
Lactococcus lactis
Bifidobacterium longum
Bifidobacterium lactis
Bifidobacterium bifidum
Streptococcus thermophilus

Natural Prebiotic Dietary Ingredients

Chicory Root Fiber - 50 mg
Fennel Seed - 50 mg

Other Ingredients

Psyllium Seed Husk

Suggested Use for General Wellness

Suggested dose is 1/8 tsp per 30 lbs per meal. It is best to mix with a small amount of water first and then mix into food especially with kibble pet food. For pets new to digestive enzymes, begin with 1/4 dosage and work up to recommended dosage as animal adjusts.

Intensive Use for Health Challenges:

May double dosage to help deal with digestive, degenerative and numerous other health challenges for as long as necessary or as directed by a holistic practitioner.


Start at 1/4 dose and gradually work up to suggested dose as your dog or cat dispays no digestive discomfort. An animal with digestive imbalances, which are many because of the over use of antibiotics, may need to build up to the suggested dosage very slowly as their digestive tract adjusts and rebalances.

This is a powerful formula and will help to rebalance your pet's digestive tract, which is a very good thing, but for those with a serious imbalance, such as Candida overgrowth and biofilm in the digestive tract, it may take some time. Because of this there may be signs of detox so go slow if necessary maybe even starting with a tiny pinch in each meal and building up from there.

Storage: Store in refrigerator when received.

Enzyme Supplement for Dogs Serving Size

Approximate Daily Servings per Container (2 meals per day)

Container Size 15 lbs 30 lbs 45 lbs 60 lbs
45 gram
150 75 56 37
90 gram
300 150 112 75
6 ounces
566 283 212 141

BioPreparation is the finest microalgae supplement for your dog or cat. We are the experts when it comes to the use of this supplement for your pets!


Premium Elk Velvet Antler for your dogs and cats. Our Elk Velvet Antler is sourced from the finest farms in Canada and is a natural, whole-food supplement containing a wide range of nutrients shown to help provide relief from pain and inflammation while promoting the healing and repair of damaged tissue.


Our Colostrum Powder for dogs and cats is the finest 100% human-grade colostrum available for your animal. Certified True Colostrum by Cornell University, it is 6-hour, first-milking colostrum and is tested ORGANIC free of herbicides, pesticides, hormones, antibiotics and steroids.


Our Systemic Enzyme Formula was developed after years of work with systemic enzymes on various pet and human imbalances such as arthritis, injury, allergies, Candida and auto imune conditions. This special formula is one-of-a-kind, there is nothing else like it in the pet marketplace. It contains a blend of enzymes that will work to help with a number of different challenges that many animals will unfortunately experience in their life times.

Follow the links below to view Natural Pet Health Protocols in which this product is included. We have created these protocols using our years of experience working with dogs and cats. Protocols are a group of supplements that work together to help support weak organs and glands and improve overall health. They can be very powerful at solving many pet health complaints and often result in true healing. We feel they are a much better alternative to medications that basically just suppress symptoms and often have many serious side-effects. There may be a time and place for prescription drugs, however we feel that time is after a safer and more natural approach has been tried.



Autoimmune Conditions



Inflammatory Bowel Disease

Skin Conditions

Urinary Tract Infection

I have been using PHNC’s Digestive Enzymes and Probiotics for both of my dogs for over a year now. In my opinion, PHNC’s Digestive Enzymes and Probiotics are the best on the market. Both of my pups have good breath and healthy bowel habits. One of my dogs has had a lifetime of digestive issues and this is the only digestive enzyme on the market that eliminates stomach gurgling. This has been an excellent formulation for my dogs
This has been my go-to absolute favorite to use for my French Bulldog who’s been having digestive issues lately. I’m never without it and use it with the Stomach Soother and Repair and Strengthen. This, along with your other various products, has been so helpful, a big factor is its also natural, not full of chemicals. So I’m safe in the knowledge that it not only benefits him but doesn’t harm him as well.

From all the way in Manila, Fudge and I thank you!
The digestive enzymes are far superior to our vet's enzymes. These are really making a difference for our dog Winston. Thanks for making such great products.
My dog, Winston, is doing much better on this formula than what I had previously purchased from my vet. They only prescribed pre and probiotics. I have also changed his diet to include raw meats and vegetables ground psyllium seeds and chia seeds. He also gets fresh blueberries and apple slices. He no longer needs as much stomach soother. He has not had bout of diarrhea since these changes. He is a senior but looks and acts like a big puppy. Thank you for you excellent pet products.
I have 4 dogs. 2GS and 2 Aussie's. Started using these on my special needs GS due to all the antibiotics he was on over these years and this stuff help a lot. Started my other 3 dogs on these and they are all doing great. No odor problems , no bad breath and there coats look awesome. They are also on the multi dose vits which I love. All have a lot of energy and my special needs one has more energy after being on the digestive enzymes and multi dose vits than he did months ago. I highly recommend both of those products.
My Boxer had such bad digestive problems he was vomiting. After using your products my boy is like a new dog can't thank you enough!

This has worked wonders for clearing up my cat's chronic diarrhea. He didn't like it in his food, so I put it in his drinking water, which he doesn't seem to my. In fact, both cats consume it this way. My cat's fur feels better and hairballs have become a thing of the past. Love the fact that all products are free of chemicals, additives, dyes, are organic and totally whole food.
My 16 year old poodle/mix dog was having bouts of gas after each meal. It was difficult to have her near after her feeding (she is a lap dog) and after just a couple of days of adding this wonderful product to her food, the gas has all but stopped! I personally believe her immune system is stronger after 2 months of using this product, as she has been exposed to another pet in the home with an upper respiratory condition. I applaud this product loudly - Thank you!
My Chow Chow had loose stools for his first two years, nothing worked. Adding this to his food has cleared up the problem!
We (the dogs and I) absolutely love this product! I give it to my Shorkie puppy and Morkie adult dog. The Morkies tear stains have improved tremendously and I feel confident about what is in the product and that it is safe for them. Because it is so pure and potent, I did have to purchase extra tiny measuring spoons off Amazon for the dosing (they get about 1/32 tsp) but it is well worth it! Thank you for a great product with no artificial crap!
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Digestive Enzymes and Probiotics Customer Testimonial

All of the Pet Health & Nutrition Center digestive products are an enormous help to my dog Ziva. Now 4 year old today, she continues to thrive because of the quality and right-targeted products we use every day.
Thank you!
M. Lindquist