Addison's Disease in Dog

Addison's Disease Holistic Protocol for Dogs has been developed by a certified Master Herbalist and certified Canine Nutritionist with The Pet Health and Nutrition Center. Our Addison's Protocol is the finest coordination of science and research-based recommendations that include diet, supplementation and herbal remedies to help support your dog with Addison's disease. Everyone here at The Pet Health and Nutrition Center truly cares and wants to help your pet get better, so give our suggestions a try because we are confident you will be

Options for Treating Addison's Disease in Dogs


1. What is Addison's Disease in Dogs?

Addison's disease, also called hypoadrenocorticism, occurs when there is a decreased output of steroid and stress hormones by the adrenal glands. The adrenal glands are often called the stress glands as they are responsible for the production of epinephrine (adrenalin) and norepinephrine by the adrenal medulla that help regulate the nervous system, heart rate, respiration as well as the "fight or flight" response. The adrenal cortex portion of the adrenal glands produces glucocorticoids and mineralocorticoids that help to control blood sugar levels and regulate the amount of sodium and potassium in the blood. You can see how the loss of adrenal function can be life threatening and, as a result, proper medical attention as well as a thorough wellness program is necessary for long term success in treating Addison's Disease in dogs and cats.

What are the symptoms?

The symptoms of Addison's disease can be very unclear and many animals may have symptoms for a long time before the disease is diagnosed. In addition, symptoms may wax and wane, further complicating the diagnosis. An extreme presentation of Addison's Disease is an episode called an 'Addisonian Crisis.' In this scenario, an animal can experience extreme weakness, confusion, vomiting, and a big drop in blood pressure due to an extremely low level of cortisol. If left untreated this episode can lead to shock, seizure or coma. Unfortunately, due to the lack of a previous diagnosis an Addisonian Crisis may be the first time the pet owner becomes aware their animal has this condition. The more common symptoms of Addison's Disease are:

  • Lethargy
  • Muscle weakness
  • Vomiting
  • Lack of appetite (anorexia)
  • Tremors or shaking
  • Diarrhea

Other symptoms of Addisons include:

  • Weight loss
  • Increased frequency of urination (polyuria)
  • Increased thirst (polydipsia)
  • Depression
  • Dehydration
  • Weak pulse
  • Low temperature
  • Blood in feces
  • Hair loss (alopecia)
  • Painful abdomen

When does it typically occur?

Addison's Disease is primarily a disease of young to middle-aged female dogs and it is rare in cats. However, since this condition has been linked to the use of vaccinations and corticosteroids, an animal of any age and either sex can develop the disease.

In What breeds/sex is it most common?

Some feel That Addison's Disease does not appear to be more common in any one particular breed. However, taking the link with vaccinations into account, those breeds or families of dogs susceptible to or affected with immune dysfunction, immune-mediated disease, immune-reactions associated with vaccinations, or autoimmune endocrine disease (e.g., thyroiditis, Addison's or Cushing's Disease, diabetes, etc.) should take great care with the vaccinations they get their animals. These dogs include: Dachshund, Akita, Weimaraners, Standard Poodles, American Eskimo, Old English Sheepdogs, Pit Bulls, Irish Setters, Kerry Blue Terriers, and Cavalier King Charles Spaniels.

2. Causes of Addison's Disease

There are a number of different possible causes for the failure of the adrenal glands. It is believed the most common is destruction of the glands in a process in which the body attacks and kills its own tissue known as 'immune mediated destruction'. This is why many animals are diagnosed shortly after a vaccination or application of a topical flea and tick product, both of which can cause an exaggerated immune reaction. Other causes can be infections, tumors, or interruption in blood flow to the gland.

Another cause of Addisons can occur if the hypothalamus stops producing proper levels of CRH (Corticotropin-releasing hormone), which is a hormone that controls the pituitary gland's secretion of hormones that influence the adrenal glands. Or, it can be the failure of the pituitary gland to secrete ACTH (Adrenocorticotropic hormone), which is a hormone that stimulates the adrenal glands to work properly. Failure of the hypothalamus or pituitary gland is usually a result of a tumor, inflammation or injury.

3. Standard Veterinary Medicine Approach

Diagnostic Testing

Since Addison's Disease has such a wide variety of symptoms, the actual diagnosis often comes after several other tests are used to rule out more common diseases. For instance, if a dog or cat presents with a history of weight loss, lethargy, or muscle weakness, which are the symptoms of many diseases, a chemistry profile and blood count are usually performed first to look at a number of body systems. Animals with Addisons often have elevated blood urea nitrogen (BUN) and creatinine (which could result in a renal failure diagnosis), lower levels of sodium (hyponatremia) and chloride (hypochloremia), increased levels of calcium (hypercalcemia), increased liver enzymes, including ALT and AST, decreased blood glucose and a blood count may show chronic anemia.

If these other diagnostic tests point to the possibility of Addison's Disease, a veterinarian will then usually use a blood test called the ACTH stimulation test. In an ACTH challenge test, the dog is given an injection of the adrenal stimulating hormone ACTH. A normal dog will respond by having an increase in blood cortisol. If a dog with Addison's Disease is given ACTH, the dog will not have an increase in blood cortisol and the diagnosis of Addisons can be made.


The standard treatment for Addison's Disease involves replacing the mineralocorticoids and glucocorticoids in the body that are not being properly supplied by the adrenal glands. This treatment will require constant monitoring and adjustment as situations change in your animal's life and as your animal ages and require the use of a commonly prescribed medication. Initially, the blood sodium and potassium levels are monitored to help obtain the correct dose. After the animal is regulated, then the levels are rechecked at least 2 to 3 times a year and adjustments in dosing are made as needed.

Recently, a newer option in the treatment of Addison's disease is an injected drug that is longer acting and only needs to be given once every 25 days. Some feel that this drug has been shown to provide better electrolyte regulation.

In an Addisonian Crisis extremely low levels of cortisol can cause sudden dizziness, vomiting and even loss of consciousness. This can be extremely dangerous if cortisol levels aren’t replenished. It’s a life-threatening condition that requires immediate medical treatment. Animals that are experiencing an Addisonian Crisis typically get an immediate injection of cortisol in a muscle or vein. If you have an animal diagnosed with Addisons it would be a good idea to have an emergency kit that includes a pharmaceutical cortisol injection. Your veterinarian can show you how to give your animal an emergency injection. It may also be a good idea to teach a family member or friend how to give an injection properly. You may want to keep a spare kit in the car if you’re a frequent traveler.

Electrolyte levels can also cause an 'Addison's Crash' in animals with the primary form of the disease. This occurs because potassium levels elevate and disrupt normal functions of the heart that can result in arrhythmia and blood pressure drops to dangerously low levels.

Primary Addison's Disease - The cortex of both adrenal glands are usually destroyed, disrupting the production of cortisol and aldosterone requiring the use of pharmaceutical drugs.

Secondary Addison's Disease - Results from failure of the pituitary to stimulate the adrenals with adrenocorticotropic hormone (ACTH). There are no changes in electrolyte levels as with Primary Addisons so only glucocorticoids (cortisol) needs to be replaced with pharmaceutical drugs.

Atypical Addison's Disease - Similar to Primary Addisons in that the adrenals are not functioning properly, but in this case the adrenals only fail to provide the glucocorticoid hormones, so the electrolytes are usually normal. Only glucocorticoids (cortisol) needs to be replaced with pharmaceutical drugs.

It is important to note that Atypical Addisonians can become Primary Addisonians. This bears watching via regularly scheduled blood testing to evaluate their electrolytes. This would require the addition of a mineralocorticoid replacement. Blood work every 3-4 months is usually recommended.

4. Natural Addison's Disease Protocol for Dogs and Cats

The goal of our Natural Addison’s Disease Protocol is to support the glands (hypothalamus, pituitary and adrenal) that play a role in proper adrenal hormone secretion so the body can grow stronger and potentially be able to maintain or contribute to this balance on its own*. When medications are used to accomplish this alone, the end result will be two very small, shriveled adrenal glands and a lower quality of life for the animal, so our protocol can play an important supportive role. If medications can be reduced when using our protocol this must be done in conjunction with your veterinarian so your animal can be properly monitored.

Core Recommendations Suggested products are included in the Core Addison's Disease Package found below.

Our "Core Recommendations" form the backbone of our Natural Addison's Disease Protocol. They consist of the supplement recommendations we feel are the most important to provide to your animal companion for this condition. They are displayed individually or as a package at the bottom of this page along with other helpful products from which you may make additional selections. Pet foods can be purchased at your finer, local pet stores. If you desire more individualized attention please feel free to use our Consultation Form to provide detailed information about your dog or cat so we can better help you.

Vitamin Supplement for Treating Addison's Disease in Dogs

 Core Recommendation #1 - Daily Multi Plus

Our Daily Multi Plus is formulated with organic, whole foods that are extremely important to an animal's nutritional needs but are often missing from the majority of canine and feline diets. This special formula provides the enzymes, probiotics, prebiotics, glandulars, vitamins, minerals, antioxidants and phytonutrients that are so beneficial to the body's daily maintenance and repair needs for healthy aging. In this formula you will find the vitamins, minerals and antioxidants recommended by the veterinarian community for this condition - only in an organic, whole food form!

Adrenal Tonic for Dog Addison’s Disease Symptoms

 Core Recommendation #2 - Adrenal Tonic

This is an herbal remedy formulated by a certified Master Herbalist using USDA organic herbs specifically for those dogs and cats suffering with Addison's Disease. It features potent herbs that support the hypothalamus, pituitary and adrenal glands that together are so important for balancing the levels of glucocorticoids like cortisol in the body. This formula will help to strengthen your animal and their resistance to stress and illness while reducing the uncomfortable symptoms of Addisons.

Biopreparation F3 for Symptoms of Addison's Disease in Dogs

Core Recommendation #3 - BioPreparation Microalgae Formula

This special blend of four unique algae was developed by a Russian Scientist, Dr. Michael Kiriac after decades of research. It is grown in controlled hydroponic conditions so it is the purest microalgae supplement on the planet. Its thousand of nutrients are so bioavailable they do not have to be digested, they easily pass through the digestive tract and feed cells on a cellular level. BioPreparation can cross the blood brain barrier to feed the brain, support the hypothalamus (so important for Addison's Disease) to help balance the entire endocrine system and even cross the blood retinal barrier to nurture the eyes. We have had outstanding success with this product so it is a Core Recommendation. Select the F3+ Forte for this condition.

Highly Recommended

Recommended Diet for Dog Addison’s Disease Symptoms

 Whole Food Nutrition

With a serious condition like Addison's Disease, in which the body needs the highest value nutrition possible so it has the energy necessary to rebalance itself, we highly recommend a raw food diet. Raw food is how carnivores, like canines and felines, have evolved to eat and they do best on a high protein, low carbohydrate diet. This is, unfortunately, the opposite of how most pets are fed since the majority of commercial diets are low protein with 50% or more carbohydrates.

In addition, kibble diets are harder for an animal to digest and this is the last thing your pet needs at this point. Since lean muscle can be lost as part of the Addison's Disease process without the right nutrition that is easily digested, absorbed and metabolized your animal will have a more difficult time getting better. If a raw food diet is not your cup of tea, the next best thing would be a cooked, whole food diet. There are now many quality premixes to choose from to which you can add your own raw or cooked meat. If you decide to make a homemade diet please research the proper way to do this and make sure to add a calcium source. For a quick and easy way to add high-quality protein to your pet's diet take a look at our Whey Protein Isolate. For more information read our articles How to Feed Your Dog or How to Feed Your Cat that can be found in our Education section.

Immune Balance for Addison’s Disease in Dog

 Immune Balance

This formula contains organic herbs recognized for their ability to support a healthy immune response. The majority of Addison's cases are believed to be the result of an autoimmune condition that destroys adrenal gland tissue. If your animal's condition is believed to be related to an overactive immune response this would make a good addition to your pet's holistic protocol.


Colostrum for Treating Addison's Disease in Dogs


Colostrum is the "first milk" produced by the mammary glands of mammals. It contains numerous beneficial compounds, but the one we will focus on for Addison's Disease is the proline-rich polypeptides. This constituent has been shown in studies to inhibit the over-production of T-cells and other immune cells that play a role in aggressive immune reactions.

By exercising your dog you will help to maintain or potentially increase lean muscle mass and naturally help to balance levels of stress hormones in the body. Exercise also acts to benefit the lymphatic system helping the body to eliminate metabolic waste. It is important not to overdo exercise sessions by taking the age and fitness level of your animal into account. Smaller more frequent sessions may be better than one longer, more demanding one.


Stress can aggravate the symptoms of Addison's Disease or even bring on an Addisonian Crisis. It is very important to create the least stressful lifestyle for your animal with Addisons. Try to maintain a uniform schedule as animals like this. Also, try to provide good leadership which makes your animal feel secure and protect them from situations that may cause them stress such as encounters with scary dogs. Maintain a low stress environment in the house as much as possible and this will benefit your animal tremendously.

Vaccinations and Toxins

Vaccinations and/or toxins from topical flea and tick products, household cleaners or lawn chemicals may have caused or contributed to your animal's Addison's Disease. Vaccinations should be avoided for those with Addison's and you should be able to get an exemption for the rabies vaccination with a letter from your vet (read our article: Are You Over Vaccinating Your Dog or Cat). Topical pesticide products would be a big 'no' for your animal and you should eliminate their exposure to household and lawn chemicals for the good of their long term health.


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5. Natural Remedies for Dogs and Cats with Addison's Disease

Addison's Package for Dogs and Cats
Our Addison's Package for dogs and cats consists of the three products we consider to form the foundation of our Natural Addison's Disease Protocol. It consists of our Adrenal Tonic Formula, Biopreparation F3+ Forte, and Daily Multi Plus. You may...
from $101.90
Adrenal Tonic for Dogs and Cats
Adrenal Tonic for dogs and cats is the premier hypoadrenocorticism remedy for animals formulated using USDA ORGANIC HERBS and USP ORGANIC VEGETABLE GLYCERIN with NO added ingredients like chemical flavorings. Formulated by a certified Master Herbalist this is a remarkable...
from $24.95
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Adrenal Glandular for Dogs and Cats
Our Adrenal Glandular for dogs and cats is one of the simplest, safest and effective Holistic modalities available to us. Essentially, the science behind the use of an adrenal glandular for pets, is that glands, when taken internally, support and...
Daily Multi Plus for Dogs and Cats
Our Daily Multi Plus is a premier supplement for dogs and cats featuring organic, whole food nutrition. This 3-supplements-in-1 formula was created in response to our clients’ requests to simplify their animal’s supplement regimen and is sure to exceed even...
from $26.95
BioPreparation F2 F3 for Dogs and Cats
BioPreparation is more than just a spirulina supplement for dogs and cats. It is a blend a FOUR microalgae strains, chosen from thousands, that make this supplement FAR superior to ordinary synthesized vitamin & isolated mineral supplements(1)! Biopreparation F2 Core...
from $29.00
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