Answer
Jan 12, 2026 - 08:52 AM
Simparica Trio® can potentially impact a dog's brain by affecting the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system, which in rare cases can lead to neurological adverse reactions such as tremors, ataxia (difficulty walking), and seizures. Buck Mountain Lepsilyte can help to support and calm the neurological system and may be able to help your dog. The herbs in the formula, skullcap and valerian, have been shown to have a calming effect on the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system. You can also research, or discuss with your veterinarian, GABA supplementation to see if that may also be helpful for your dog. I would also consider Biopreparation F2 Core as this microalgae supplement can cross the blood-brain barrier to support the health neurological system.
